Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Gravel
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A deposit of small calculous concretions in the kidneys and theurinary or gall bladder; also, the disease of which they are asymptom. Gravel powder, a coarse gunpowder; pebble powder.
Gravel meaning & definition 1 of Gravel.
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One rock is a rock. Two rocks = gravel.
Gravel meaning & definition 2 of Gravel.
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A new drug surfacing in the New York City area that is a combination of meth, bath salts, and cocaine.
Gravel meaning & definition 3 of Gravel.
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Pocket change, especially coin
Gravel meaning & definition 4 of Gravel.
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Refering to A Homosexual Experience were the act is taken place outside the club in the Parking Lot. Or Doing Such and act on the Hood Of the Car in the parking lot of the Club.
Gravel meaning & definition 5 of Gravel.
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(Google Travel) Like window shopping is to retail, gravel is to globe trotting but through google maps or google earth.
Gravel meaning & definition 6 of Gravel.
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A term used to describe something that everybody loves. It probably came about because nobody can dislike gravel.
Gravel meaning & definition 7 of Gravel.
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The lowest point you can wear your trousers without them either falling down or exposing your genitals.
Gravel meaning & definition 8 of Gravel.
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adj. Something that is awesome or cool; [beast].
Synonyms; [beast], [awesome], [tank], [cool], [rad],
Gravel meaning & definition 9 of Gravel.
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small pieces of turds when they fall apart
Gravel meaning & definition 10 of Gravel.
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Your hood, your spot, neighborhood
Gravel meaning & definition 11 of Gravel.
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A loose aggregation of small water-worn or pounded stones.
Gravel meaning & definition 12 of Gravel.
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Refers to a [revenge sex] act, specifically, to consume [grape nuts] [prior to] performing oral sex on another individual. The intention is to cause physical pain.
Gravel meaning & definition 13 of Gravel.