Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Dude
-
A kind of dandy; especially, one characterized by anultrafashionable style of dress and other affectations. [Recent]The social dude who affects English dress and English drawl. TheAmerican.
Dude meaning & definition 1 of Dude.
-
A word that americans use to address each other. Particularly stoners, surfers and skaters.
Dude meaning & definition 2 of Dude.
-
- The Universal Prounoun
- Adj - expression of emphasis, amazement, or awe
Dude meaning & definition 3 of Dude.
-
- n. a name for anyone (stereotypically used by male surfters/skaters but now accepted by any race, sex, religion, and wealth)
- n. something that's just so awesomly cool, amazingly kick ass
- ?. a way to start a conversation
- replacing um or like in any sentence
Dude meaning & definition 4 of Dude.
-
'dude' is a universal word, used in every possible corner of the globe, in every possible situation
Dude meaning & definition 5 of Dude.
-
-
Originally, “dude” meant a stuck up person who dressed overly well. It first emerged in the year 1883 in England.
-
Later it was used in the old west to mean a city person who moved to the west without actually know what he was doing. Synonymous with “city-slicker”
-
Later, in California, the term changed from these insults to a term meaning any male, human or otherwise. Sometimes it is used in reference to tom-girls. Now, it is often used for emphasis as well.
Dude meaning & definition 6 of Dude.
-
-
A brilliant word that has infinite definitions and meanings. The user can say it in almost any situation and still make sense
Dude meaning & definition 7 of Dude.
-
Absolutely anything at all. Whatever you what it to be.
Dude meaning & definition 8 of Dude.
-
n
Informal- A word which refers to a city dweller who vacations in the west.
- In the west, a person who is very fancy and/or dresses sharply
- A man or fellow
- A person of either gender, used as a term of endearment or friendliness
- A person of either gender used as a general term, not necessarily of endearment.
- An interjection of happiness, satisfaction, or awe
- An interjection of dissapointment or sympathy
- Oh, fuck it. Dude can mean anything, you retards. It can probably be a fucking verb, for God's sake.
Dude meaning & definition 9 of Dude.
-
-
An aggravated hair on an elephant's butt.
-
The substitute for someone's name when you don't quite know it properly
Dude meaning & definition 10 of Dude.
-