Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Clockwise
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Like the motion of the hands of a clock; -- said of thatdirection of a rotation about an axis, or about a point in a plane,which is ordinarily reckoned negative.
Clockwise meaning & definition 1 of Clockwise.
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To be really proud of having a digital watch that shows seconds, almost a desease.
Clockwise meaning & definition 2 of Clockwise.
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in the direction in which the hands (= thin parts that point) of a clock move:
Clockwise meaning & definition 3 of Clockwise.
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In the same direction as the way in which the hands of a clock move around.
Clockwise meaning & definition 4 of Clockwise.
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