Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Debit
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A debt; an entry on the debtor (Dr.) side of an account; --mostly used adjectively; as, the debit side of an account.
Debit meaning & definition 1 of Debit.
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A non-committal acknowledgment of another's opinion or comment.
Debit meaning & definition 2 of Debit.
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Chicks that go ass to mouth ATM
Debit meaning & definition 3 of Debit.
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De binary digits.
Debit meaning & definition 4 of Debit.
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the butt
Debit meaning & definition 5 of Debit.
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An entry recording a sum owed, listed on the left-hand side or column of an account.
Debit meaning & definition 6 of Debit.
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