Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Barbarians
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Guys, usually Yuppies, who frequent bars looking to get laid. You can spot them by their snazzy striped shirts and Goldman Sachs business cards.
Barbarians meaning & definition 1 of Barbarians.
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a member of a group of people from a very different country or culture that is considered to be less socially advanced and more violent than your own:
Barbarians meaning & definition 2 of Barbarians.
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