Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Perturbation
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A disturbance in the regular elliptic or other motion of aheavenly body, produced by some force additional to that which causesits regular motion; as, the perturbations of the planets are causedby their attraction on each other. Newcomb.
Perturbation meaning & definition 1 of Perturbation.
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The act of pleasuring oneself whilst anxious or unsettled.
Perturbation meaning & definition 2 of Perturbation.
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When one masturbates to pornographic material that's extremely perturbing, raunchy, disgusting, or so obscurely erotic that it is hard to consider it porn.
Perturbation is NOT a synonym to [disturbation], which refers to the methodology of masturbation rather than the subject matter.
Perturbation meaning & definition 3 of Perturbation.
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A [deviation] in the state or [complex] motion of a system, moving object or massive body - caused by outside [influences] or third parties.
Perturbation meaning & definition 4 of Perturbation.
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Anxiety; mental uneasiness.
Perturbation meaning & definition 5 of Perturbation.
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