It’s just a play on words that his [pockets] are “[stuffy]” (stuffed with cash), and the irony of the reference to antihistamine which would clear up [a stuffy] nose, but clearly has nothing to do with pockets stuffed with cash.
Antihistamines
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a type of drug that is used to treat medical conditions caused by an extreme reaction to particular substances:
Antihistamines meaning & definition 1 of Antihistamines.
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a drug taken to limit the bad effect of the body’s reaction to some substances:
Antihistamines meaning & definition 2 of Antihistamines.
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