Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Dirge
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A piece of music of a mournful character, to accompany funeralrites; a funeral hymn.The raven croaked, and hollow shrieks of owls Sung dirges at herfuneral. Ford.
Dirge meaning & definition 1 of Dirge.
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Dirge is an epic dagger from the mmorpg wow, wich one day for unknown reasons, became the object of the longest spam session in tradechat ever.
Dirge meaning & definition 2 of Dirge.
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a song played during a funeral
Dirge meaning & definition 3 of Dirge.
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An item within the game World of Warcraft of epic quality. The item has been the subject of an in-game fad, where it has been exessively linked in chat channels (spammed), usually in along with attempts at a humorous segway, and/or replacing a word in a sentence with the item name.
Responses to the spamming, which can occur over several hours/days, is usually received with contempt, which incites the bandwagoners to increase their spamming.Dirge meaning & definition 4 of Dirge.
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A sad pirate song, played during times of extreme lamentation.
Dirge meaning & definition 5 of Dirge.
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There are five prime classifications of dirge:
- Trad Dirge
- True Dirge (also known as Pure Dirge)
- Dirge (also know as Standard Dirge)
- Sub Dirge
- Fake Dirge
However, there are offshoots such as Math Dirge, Nu Dirge, Black Dirge, Dirge Punk, Dirge Core, Neo-Classical Dirge, Prog Dirge, Nintendirgecore etc but they generally are derivative of one of the five main classifications.
Dirge meaning & definition 6 of Dirge.
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One of the six scout class found in the online multiplayer game, Everquest 2. Dirges have musical spells and are generally considered a support utility class used for providing offensive group buffs to other Fighter and Scout classes ingroup.
Dirge meaning & definition 7 of Dirge.
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Australian slang for a [cone] of bong [resin] mixed with tobacco. Often smoked as a last resort.
Dirge meaning & definition 8 of Dirge.
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a long, drawn out, soul draining noise
Dirge meaning & definition 9 of Dirge.
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To cum unexpectedly and violently, often releasing a large amount.
Dirge meaning & definition 10 of Dirge.
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Another term to mean the same as rubbish.
Dirge meaning & definition 11 of Dirge.
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A lament for the dead, especially one forming part of a funeral rite.
Dirge meaning & definition 12 of Dirge.
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[Codeword] often used by homosexual [predators] to [announce] their presence to other predators in a cyber-environment. This is to ensure they dont accidentally court each other into a conversation. These types of predators generally are homosexual and pedophiles.
Dirge meaning & definition 13 of Dirge.
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a slow sad song or piece of music, sometimes played because someone has died
Dirge meaning & definition 14 of Dirge.