Cankered

[Donald Trump]

Affected mentally or morally as with canker; sore,
envenomed; malignant; fretful; ill-natured.

[Lanell]

A nasty, dirty and often diseased [whores crotch]. Typically the [filthy crotch] and [neither region] of a [prostitute], [meth whore] or [crack whore] or just a chick with a dirty, cankered up crotch.

[Julian]

verb - being completely utterly fucked up
adj - corrupt, down right wrong
noun - a worthless bastard

(born through first use on August 29, 2005 through the creative stylings of R

[Dorothey Allen]

a cankered tree or fruit is affected by the canker disease:

[Cami]

(of a plant or part of a plant) affected by canker.