Disorders of neuromuscular transmission

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Disorders of neuromuscular transmission affect the neuromuscular junction; they commonly cause fluctuating fatigue and muscle weakness with no sensory deficits.
(See also Overview of Peripheral Nervous System Disorders.)
Disorders of neuromuscular transmission may involve

Postsynaptic receptors (eg, in myasthenia gravis)
Presynaptic release of acetylcholine (eg, in botulism)
Breakdown of acetylcholine within the synapse (eg, due to drugs or neurotoxic chemicals)

Some disorders that affect other areas of the body primarily (eg, stiff-person syndrome, Isaacs syndrome) have neuromuscular manifestations.