Isaacs syndrome

[Becky]

Isaacs syndrome is an autoimmune peripheral nerve disorder that causes neuromuscular manifestations, including continuous muscle twitching (myokymia).
(See also Overview of Peripheral Nervous System Disorders.)
Isaacs syndrome (neuromyotonia) is an autoimmune peripheral nerve hyperexcitability syndrome, generally thought to be a voltage-gated potassium channelopathy; it sometimes occurs as a paraneoplastic syndrome. It may also accompany other disorders (eg, myasthenia gravis, thymoma, Hashimoto thyroiditis, vitamin B12 deficiency, celiac disease, connective tissue disorders) or can be inherited.
Cause of Isaacs syndrome is unknown. Abnormalities are thought to originate in peripheral nerves because abnormalities are abolished by curare but usually persist after general anesthesia.