Perforations of the septum

[Cami]

Inside the nose is the nasal cavity, which is divided into two passages by the nasal septum. The nasal septum is composed of both bone and cartilage and extends from the nostrils to the back of the nose.
Ulcers (sores) and holes (perforations) in the nasal septum may occur as a result of

Nasal surgery
Repeated injury (such as from repeatedly picking the nose)
Cosmetic piercing
Exposure to toxins (such as acids, chromium, phosphorus, and copper vapor)
Chronic nasal spray use (including corticosteroids and over-the-counter phenylephrine or oxymetazoline sprays)
Pure oxygen inhaled through the nose, as is delivered through nasal prongs or a nasal mask
Diseases such as tuberculosis, leprosy, granulomatosis with polyangiitis (formerly called Wegener granulomatosis), and syphilis
Frequent use of cocaine snorted through the nose (because it decreases blood flow)