Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Toner
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A musical boner. Being sexually attracted to a person because of their musical talent. A term made popular, if not coined, by the movie Pitch Perfect.
Toner meaning & definition 1 of Toner.
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A nickname for a canadian drunk who comes down to Lakewood every year and gets hammered out of his gourd. Known to wet himself on numerous occasions. Might be seen with a smoke in one hand and a beer in another. Will eat or drink crazy things for bets. Will fester in own juices. Beware
Toner meaning & definition 2 of Toner.
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A boner you get from great tone.
Toner meaning & definition 3 of Toner.
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a [nipple] that is erect, poking through the shirt
Toner meaning & definition 4 of Toner.
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to-ner (noun): an erect [nipple]. This usually occurs when it is cold. The words origin lies in the ingenious combination of the words [tit] and [boner], giving us toner.
Toner meaning & definition 5 of Toner.
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the toner is an alcoholic beverage made from spiced rum (preferably Captain Morgans) and orange crush - it is not for the feint of heart or those with taste buds
Toner meaning & definition 6 of Toner.
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A toner is a technical boner - when someone gets way too excited about a technical / geeky subject / item
Toner meaning & definition 7 of Toner.
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Toner is another definition of a handgun. More commonly used for a nine millimeter. Often used by three six mafia.
Toner meaning & definition 8 of Toner.
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Toner meaning & definition 9 of Toner.
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A noun; person, loser-ish, selfish and moody. But thats what makes him flawless.
Toner meaning & definition 10 of Toner.
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An astringent liquid applied to the skin to reduce oiliness and improve its condition.
Toner meaning & definition 11 of Toner.