Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Bondage
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Tying up or restraining your consenting sexual partner.
Usually the restraining is done by the dom (dominant) and the sub (submissive) is the one restrained.
Sexually arousing for some, as the exchange of power is exciting, and the helplessness of being bound allows some people to really let go and enjoy themselves. Also, having complete control over a willing partner is very arousing. There are many reasons people enjoy this.HAS NOTHING TO DO WITH VIOLENCE.
Bondage is often used in conjuction with punishment/pain play, but it is NOT the same thing!!!Bondage meaning & definition 2 of Bondage.
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The practice of being restrained for sexual gratification.
Bondage meaning & definition 3 of Bondage.
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The consensual and romantic restraint of a beloved and cherished partner for mutual sexual enjoyment
Bondage meaning & definition 4 of Bondage.
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The act of tying someone up for sexual pleasures
Bondage meaning & definition 5 of Bondage.
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Bondage does not mean using leather objects for sexual pleasure. It means being restrianed /tied and can be done with a variety of materials - ie ropes, scarves, rubber, leather thongs, cling film, chains etc
Bondage meaning & definition 6 of Bondage.
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Using restraining objects (e.g. Handcuffs) on a consenting partner during sex.
Some people confuse bondage with BSDM, but bondage and BSDM are quite different: BSDM is the act of hurting someone during sex, bondage is simply restraining them.
Bondage meaning & definition 7 of Bondage.
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Another, non-sexual, definition of this widely used term referring to the tragic occurence of what happens when one accidentally super glues one body part to another resulting in a semi-permanent bond that is both frustrating and painful to separate.
Bondage meaning & definition 8 of Bondage.
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Part of a [normal] [relationship]. [Love] is Bondage. Were one person is [restrained] by something made of [leather] or rubber.
Bondage meaning & definition 9 of Bondage.
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A type of sex where a man ties up a woman and does whatever he wants to her weather its his mate or its not his mate.
Bondage meaning & definition 10 of Bondage.
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The state of being a slave.
Bondage meaning & definition 11 of Bondage.