Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Dead
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Britney Spear's career
Dead meaning & definition 1 of Dead.
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No longer alive.
Dead meaning & definition 2 of Dead.
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- The word you use when you find something [hilarious].
- Not [physically] [alive].
Dead meaning & definition 3 of Dead.
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Dead in Ice Hockey. Describes the puckwhenis eitherhit over the boards or becomes lodged in the side nettingofthe goal. Also when the puck is out of play due to a goal being scored or when the whistle blown.
Dead meaning & definition 4 of Dead.
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