Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Pauline
-
A girl who's fun and supersmart, but she'd rather be thought of as fun and hide her brains.
Pauline meaning & definition 3 of Pauline.
-
a sexy ass fine girl who can attract any guy any age. she is good at sex and will have you in love. everyone wants to be pauline.
Pauline meaning & definition 4 of Pauline.
-
Pauline's the smartest girl you'll ever meet. She has a great sense of humour and honestly you wish more people would recognise her greatness instead of being jelly little cunts because she's better than them. You'll try to seduce her many times but she's just too good for you.
Pauline meaning & definition 5 of Pauline.
-
adj : relating to Paul the Apostle or his doctrines, who was an apostle to the Gentiles whose life and teachings are set forth in his epistles and the Acts of the Apostles
Pauline meaning & definition 6 of Pauline.
-
Is the funniest and smartest girl alive.
She is beautiful and loves YouTube.
She is really tough and buff even if she is not as tall as the others.Pauline meaning & definition 7 of Pauline.
-
A lady who appears to be shy but really she's just incredibly hung over. Usually seen with a bottle of wine, if there's no bottle seen, it's usually up her sleeve.
Pauline meaning & definition 8 of Pauline.
-
Cockney rhyming slang for a growler (cf. Growler), from the character in Eastenders, Pauline Fowler.
Pauline meaning & definition 9 of Pauline.
-
Town bike!
Pauline meaning & definition 10 of Pauline.
-
A kind, generous and shy around people. Always do her work and is beyond beautiful.
Pauline meaning & definition 11 of Pauline.
-
A young girl who is easy to fall in love with a girl who takes no suger honey ice tea .Aka a boss ass bitch
Pauline meaning & definition 12 of Pauline.
-
an [amazing girl] who is easy to fall in love with but doesnt know what shes got, shy and [humble] shes always [considerate] of others yet she never settles for anything short of the best
Pauline meaning & definition 13 of Pauline.
-
Relating to or characteristic of St Paul, his writings, or his doctrines.
Pauline meaning & definition 14 of Pauline.