Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Glacier
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a chunk of ice formed from snow falling and coming together over the years and moving very slowly, either descending from high mountains or moving outward from centers of accumulation.
Glacier meaning & definition 1 of Glacier.
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when a girl looks super hot and thin sitting down or when lower half is not visible, but when you see her whole body 80% of her body weight is in the hips and below. And not in a good way, in a way that looks like she could take down the god damn titanic itself.
Glacier meaning & definition 2 of Glacier.
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Men whose minds work at the speed of 0.3 miles per year. They are very dense, slow minded, and stupid. They also do not respond appropriately, and can offend people without knowing.
Glacier meaning & definition 3 of Glacier.
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Insert ice cubes into your partners ass, then lay under them and drink the the shitty drip.
If this gets boring you can use a half order of Buffalo Wings instead of ice cubes, hence the Lava Flow.Glacier meaning & definition 4 of Glacier.
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Word for an older bisexual man who likes young boys.
Glacier meaning & definition 5 of Glacier.
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A slowly moving mass or river of ice formed by the accumulation and compaction of snow on mountains or near the poles.
Glacier meaning & definition 6 of Glacier.
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Someone who thinks that they are better than everyone else. Glaciers think that everyone is water and they are this [mighty] [formation] of [ice].
Glacier meaning & definition 7 of Glacier.
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Glacier in Skiing. An ice mass often used for summer skiing.
Glacier meaning & definition 8 of Glacier.