Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Envelope
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An ancient device to keep paper internets safe when transferring information at 3 to 5 bits per hour across the Earth.
Envelope meaning & definition 1 of Envelope.
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You lick it. It is shoved in your slot.
Envelope meaning & definition 2 of Envelope.
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to ejaculate between a womans asscheeks and hold together until theyre stuck shut.
Envelope meaning & definition 3 of Envelope.
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A sexual technique where the penis is licked from one end to the other, along the side, with rapid tongue movement similar to licking an envelope.
Similar to [corn on the cob], but the lips are not pressed to the penis.Envelope meaning & definition 4 of Envelope.
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A overly skinny, pale, white female. Most likely a scenester, but exceptions do apply (see Ellen Page).
Envelope meaning & definition 5 of Envelope.
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vagina, opening of the vagina
Envelope meaning & definition 6 of Envelope.
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Something you can send mail in. It is correctly pronounced en-vuh-lope. onvelope is a mispronunciation of the word.
See onvelope.
Envelope meaning & definition 7 of Envelope.
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To cream on a girls panties, proceeding to have her put them on and become sealed to her
Envelope meaning & definition 8 of Envelope.
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Condensed water in the sky, generally in white, that causes the rain. Cloud
Envelope meaning & definition 9 of Envelope.
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You dumbass, cant you [figure it out]... you send your [mail] in it! [duhh]!!
Envelope meaning & definition 10 of Envelope.
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A flat paper container with a sealable flap, used to enclose a letter or document.
Envelope meaning & definition 11 of Envelope.