Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Facial
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when someone cums all over your fuckin face
Facial meaning & definition 1 of Facial.
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A sexual act in which hot, sticky man-juice is spewed unto a girls face.
Facial meaning & definition 2 of Facial.
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(1)Application of make-up to ones face.
(2)Application of sperm to ones face.
Also see: [smud]Facial meaning & definition 3 of Facial.
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To cum on someones face. Often used in conjunction with cumshot.
Facial meaning & definition 4 of Facial.
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n. a form of birth control
Facial meaning & definition 5 of Facial.
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facial- verb(v.), noun(n.)
1.a: v. - The act of unloading spunk upon a man or womans face.
1.b: n. - A load of semen on a man or womans face.
2.a: v. - Deep cleansing of the face by various means including; steam, exfoliation, extraction, creams, lotions, masks, peels, and massage.Facial meaning & definition 6 of Facial.
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1.) A cosmetic treatment applied to the face.
2.) A huge load of [cum] applied to the face.Facial meaning & definition 7 of Facial.
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when a man cums over someone else(s)s face.
Facial meaning & definition 8 of Facial.
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Shooting your load over a man or womans face.
Facial meaning & definition 9 of Facial.
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When a guy shoots his load all over someones face.
Facial meaning & definition 10 of Facial.
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Of or affecting the face.
Facial meaning & definition 11 of Facial.