Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Buttle
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What a [butler] does when he works.
Buttle meaning & definition 1 of Buttle.
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The sweat that collects betwix the buttocks of any normal human, and can sometimes be infused with fecal matter, lint, and or pubic hairs. Some consider buttle on toast or frozen buttle to be a delicacy.
Buttle meaning & definition 2 of Buttle.
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a butthole or anus; the backdoor
Buttle meaning & definition 3 of Buttle.
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anal leakage; a slight diarrhaea-like discharge from the anus usually discovered at a later time.
Buttle meaning & definition 4 of Buttle.
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To push your face into, rub, cuddle, or snuggle someones butt.
Buttle meaning & definition 5 of Buttle.
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Derogatory name for an idiot.
Buttle meaning & definition 6 of Buttle.
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when your butt hole sucks up your panites
Buttle meaning & definition 7 of Buttle.
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Work as a butler.
Buttle meaning & definition 8 of Buttle.
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A different [version] of saying [butthole]. Also can be used as [dirty] slang when used.
Buttle meaning & definition 9 of Buttle.
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