Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Wince
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To shrink, as from a blow, or from pain; to flinch; to
start back.
Wince meaning & definition 1 of Wince.
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The teller of a harsh truth without sugar coating, or comforting words. A person of the offbeat and sometimes frowned upon lifestyle of American culture.
Wince meaning & definition 2 of Wince.
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Another name for alcohol. Derived from the wincing face you make when you drink
Wince meaning & definition 3 of Wince.
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basically a dickhead
Wince meaning & definition 4 of Wince.
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