Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Nobber
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someone that has just done something really stupid
Nobber meaning & definition 1 of Nobber.
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This is the millenium entry for nob deriving from the terms prick, penis, cock, dick or dickhead. Personal insult directed at the candidate for acts of pure nobberism.
Nobber meaning & definition 2 of Nobber.
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Casual insult used against someone who has done something you dont like.
Nobber meaning & definition 3 of Nobber.
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Oral sex given by a female to a male. Also- Nob Job, Nob Slobbin, Slobin the Nob.
Nobber meaning & definition 4 of Nobber.
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Someone who should be [backhanded] for being a dick
Nobber meaning & definition 5 of Nobber.
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An everyday error performed to perfection and in company. Can be used as a noun You Nobber or as an adjective That was a nobber thing to do.
Nobber meaning & definition 6 of Nobber.
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a shortened version of the word nobhead used in the east midlands originated from burton-on-trent
Nobber meaning & definition 7 of Nobber.
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also a term used for [the motorbike] [honda] [cub] 90
Nobber meaning & definition 8 of Nobber.
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Shouldn't it be spelt knobber?
Nobber meaning & definition 9 of Nobber.
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Yes, if it relates to knobs, as most responders think. If the spelling nobber is correct, then the derivation is wrong.
Nobber meaning & definition 10 of Nobber.