Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Mauritanian
-
A man from the country of Mauritania. This man is Arab and Muslim by virtue of the location of his birth. Men from Mauritania are hard workers, they are after all Africans, they manage to remain civilized and intelligent while living in arid territory. The source of their qualities (being intrepid, kind, generous, selfless) are the Mauritanian women: the most beautiful and honorable women on the face of this earth. Mauritanian women are the only kind of women that can give birth to a Mauritanian man.
Mauritanian meaning & definition 1 of Mauritanian.
-
Literally: a person from the french speaking African country Mauritania.
Figuratively: A skinny man who prefers fat women.
In the Islamic Republic of Mauritania, fat and Rubenesque women are sexy and desirable. So much so, that instead of the crash diet of the West, they have a similar but opposite program: crash feeding or gavage, where girls as young as 5 years old are force-fed milk, cream, butter, couscous and other calorie-rich food:
Girls as young as 5 and as old as 19 had to drink up to five gallons of fat-rich camel’s or cow’s milk daily, aiming for silvery stretch marks on their upper arms. If a girl refused or vomited, the village weight-gain specialist might squeeze her foot between sticks, pull her ear, pinch her inner thigh, bend her finger backward or force her to drink her own vomit. In extreme cases, girls died.
Interestingly, the ideal man is skinny (Mauritanians view portly men as womanish and lazy).Mauritanian meaning & definition 2 of Mauritanian.