Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Boated
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A girl that is thick. 2) She has thick thighs and nice hips, but far from fat. 3) A big butt, very nice looking. 4) Not a skinny girl, but she fills out clothes quite nicely. 5) Able to see her curves on sight with her clothes still on, and it make you want her
Boated meaning & definition 1 of Boated.
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A term associated with a clapped fresh person from one country of another. Often the stereotype of a race, appearing as though they need to be deported asap.
Boated meaning & definition 2 of Boated.
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adj.midwest vernacular for dressing exceeding well;very nicely clothes. probably originating from the famous urban name brand Marithe Francois Girbaud. Local idiom evolved the word into the phrase boated
Boated meaning & definition 3 of Boated.
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To run really really fast
Boated meaning & definition 4 of Boated.
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