Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Milder
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A whiny kid or a grown man who will die of stress or something related
As a kid Milder is a cry baby always wants what he wants or else he criesMight have a mental problem
Milder meaning & definition 1 of Milder.
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[ma-il-der]
A person lacking friends and or little to no social interactions. A milder is also someone who is tall and sluggish and have yet to loose their virginity and have had no affectionate interactions with a female. For example, kissing, making out, blow jobs, fingering.....etc. basically a milder is a unsocial, sluggish, tall, virgin with no ambition in life and will go no where in life.Milder meaning & definition 2 of Milder.
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not violent, severe, or extreme:
Milder meaning & definition 3 of Milder.
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