Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Murdered
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When someone says something so sweet and caring that your heart just kinda bursts and you feel like screaming but also hugging someone. Like fingering, but on a smaller scale.
Murdered meaning & definition 1 of Murdered.
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wen alcohol has beaten someone
wen they cannot move there body because
they are too drunk
(also can be from any other drug)Murdered meaning & definition 2 of Murdered.
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An expression usually said when giving props to someone who [shitted] or [shatted] or [squatted]
They did the unexpectedMurdered meaning & definition 3 of Murdered.
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past simple and past participle of murder
Murdered meaning & definition 4 of Murdered.
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