Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Gravure
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Softcore glamor photography and videos of female models in Japan. It can range from clothed and tame to nude and provocative.
(The older definition on here claimed the models were teens at the oldest, which is not true. Many gravure idols are in their 20s or older.)
Gravure meaning & definition 1 of Gravure.
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An art form popular in Japan whereby a pre-teen or teen female idol poses for clothed, semi-clothed, or nude pictures in various positions and costumes. The pictures are published in magazine form, called photobooks, featuring only this female model and no others. Gravure idols feature [race queens] and pop idols who who to achieve celebrity by selling their images.
Gravure meaning & definition 2 of Gravure.
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