Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Breastie
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A best friend of yours that has the same breast size as you
Breastie meaning & definition 1 of Breastie.
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A strong and complex nonsexual relationship between two or more females that is greater than being BFF. Similar to a bromance.
Breastie meaning & definition 2 of Breastie.
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Selfie of a womens breasts.
Breastie meaning & definition 3 of Breastie.
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The accurate term for girls who are best friends.
Breastie meaning & definition 4 of Breastie.
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Close friend possessing large cup breasts.
Breastie meaning & definition 5 of Breastie.
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Super affectionate term used when a straight male has a female best friend: ie a [bestie] with breasts. More common among men who favor brunch.
Breastie meaning & definition 6 of Breastie.
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