Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Satisfaction
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The feeling you get when you obtain one of the following: revenge, orgasm, college degree, a really hot chicks/dudes phone #
Satisfaction meaning & definition 1 of Satisfaction.
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the tangible feeling in which I demand some of.
Satisfaction meaning & definition 2 of Satisfaction.
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What you demand when someone insults your honor
Satisfaction meaning & definition 3 of Satisfaction.
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A feeling of completion; the filling of a emotional requirement.
What Mick Jagger cant get.
Satisfaction meaning & definition 4 of Satisfaction.
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A concept defined by men as a fulfilling and brief encounter with a beautiful woman.
A concept defined by women as non-existent. Suggested alternative: Doritos and dip.
Satisfaction meaning & definition 5 of Satisfaction.
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Gratification found in doing something/someone.
Satisfaction meaning & definition 6 of Satisfaction.
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a Myth for humans
Satisfaction meaning & definition 7 of Satisfaction.
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