Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Quintuple
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Multiplied by five; increased to five times the amount;fivefold. Quintuple time (Mus.), a time having five beats in ameasure. It is seldom used.
Quintuple meaning & definition 1 of Quintuple.
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When a man pops a boner and quickly starts thrusting his penis inside a woman’s pussy. But when he cream pies that clit, he still thrusts his wiener into her cervix even when his penis is now soft and a chode. The woman clenches her clit lips together, cutting off circulation to the crank, leaving it saggy and purple.
Quintuple meaning & definition 2 of Quintuple.
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Consisting of five parts or things.
Quintuple meaning & definition 3 of Quintuple.
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to increase by five times, or to increase something by five times:
Quintuple meaning & definition 4 of Quintuple.
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