Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Apples
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what the fuck are you looking at the definition of apples for you stupid fuck?
Apples meaning & definition 1 of Apples.
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The result of a mindblowing or humiliating situation in which the victim is posed one question:
Apples meaning & definition 2 of Apples.
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A shortened version of [apples and pears], which is cockneyrhyming slang for stairs.
Apples meaning & definition 3 of Apples.
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Australian Slang for good
Apples meaning & definition 4 of Apples.
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