Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Owls
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Similar to [lol], owls is something that you write when you find something amusing. The history of the phrase is quite clear, as web studies show a gradual evolution:
lol -> lols -> lawls -> jowls -> owls
Owls meaning & definition 1 of Owls.
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Obessed With Luke Syndrome
Owls meaning & definition 2 of Owls.
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