Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Hornbug
-
A large nocturnal beetle of the genus Lucanus (as L. capreolus,and L. dama), having long, curved upper jaws, resembling a sickle.The grubs are found in the trunks of old trees.
Hornbug meaning & definition 1 of Hornbug.
-
noun. Person who is always horny, a term commonly used when people do not want to be direct.
Hornbug meaning & definition 2 of Hornbug.
Similar Words