Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Roofless
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- to be without a roof or ceiling to block, in other words to be without LIMIT to the things a person can say or do.
Roofless meaning & definition 1 of Roofless.
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The slang pronunciation of Ruthless.
The term Roofless is used to define two (2) types of people:
- Acknowledge someone who has the ability to make very harsh
Roofless meaning & definition 2 of Roofless.
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