Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Dread
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To fear in a great degree; to regard, or look forward to, withterrific apprehension.When at length the moment dreaded through so many years came close,the dark cloud passed away from Johnson's mind. Macaulay.
Dread meaning & definition 1 of Dread.
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Bahamian slang for man or [bey]
Dread meaning & definition 2 of Dread.
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Popular Word, Caribean/Bahamian Roots. Showing astonishment.
Dread meaning & definition 3 of Dread.
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A person who sports the ever popular dreadlock hair style.
Dread meaning & definition 4 of Dread.
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being dread, mean
Dread meaning & definition 5 of Dread.
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Detroit Rockers Engaged in the Abolition of Disco
This was a stunt orchestrated by the Detroit, MI, hard rock radio station WRIF for see above. DREAD members pledged as follows:
I will never wear platform shoes.
I will never wear zodiac jewelry.
I will never listen to disco records and/or disco stations.
Silk dresses and three piece suits are extremely suspect.
A violation of any of these conditions is punishable by THE CHAIR.Dread meaning & definition 6 of Dread.
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A Rastafarian. Short for natty dread and derived from dreadlocks.
Dread meaning & definition 7 of Dread.
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mean, cold, heartless, dark
Dread meaning & definition 8 of Dread.
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@Jessica And what is "the chair"?
Dread meaning & definition 9 of Dread.
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Anticipate with great apprehension or fear.
Dread meaning & definition 10 of Dread.