Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Us
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Who all your base are belong to
Us meaning & definition 1 of Us.
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The mathematical sum of you and me.
Us meaning & definition 2 of Us.
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- Abreviations for the United States.
- A word that means yourself and the other people youre refering to.
Us meaning & definition 3 of Us.
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To agree. Kinda like yeah but not quite, there are subtle diversities.
Commonly used expression when consenting to group sex.
In the following examples if yeah were used the conversations would lack sincerity. On the contrary, us is far less causal and evokes genuine passion.
Us meaning & definition 4 of Us.
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The definition of badass. Complete and utter baddassness should always be refered to as us.
Us meaning & definition 5 of Us.
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*More than one person. Similar to we, only refering it to someone else instead of yourself.
Us meaning & definition 6 of Us.
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united similarly
Us meaning & definition 7 of Us.
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