Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Threadbare
-
Worn to the naked thread; having the nap worn off;
threadbare clothes.
Threadbare meaning & definition 1 of Threadbare.
-
Threadbare material or clothes have become thin or damaged because they have been used a lot:
Threadbare meaning & definition 2 of Threadbare.
-
(of cloth, clothing, or soft furnishings) becoming thin and tattered with age.
Threadbare meaning & definition 3 of Threadbare.
Similar Words