Setback

[Britney]

A backset; a check; a repulse; a reverse; a relapse.

[Ernesto]

A reversal or check in progress.

[Donald Trump]

Something that sets you back. It keeps you from doing something and can cause great [inconvenience] to someones life. A [setback] may just [knock you off] your time schedule or it could be stopping you from doing something you drastically need to do. Setbacks are not good, most of the time...