Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Rupture
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The act of breaking apart, or separating; the state of
being broken asunder; as, the rupture of the skin; the rupture of a
vessel or fiber; the rupture of a lutestring.
Rupture meaning & definition 1 of Rupture.
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To rupture (destroy) someones anus with your massive bear-cock.
Rupture meaning & definition 2 of Rupture.
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to (cause something to) explode, break, or tear:
Rupture meaning & definition 3 of Rupture.
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(especially of a pipe, a vessel, or a bodily part such as an organ or membrane) break or burst suddenly.
Rupture meaning & definition 4 of Rupture.
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