Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Pizza face
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An offensive term telling people that they have bad acne
Pizza face meaning & definition 1 of Pizza face.
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A face that is so covered in acne the skin underneath cannot be seen.
Pizza face meaning & definition 2 of Pizza face.
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A pizza face is either someone or their face that is so covered in [acne] ([pimples]/[zits]), that the skin beneath is hard to make out.
Pizza face meaning & definition 3 of Pizza face.
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A person with really bad acne resulting in a red greasy face... Just like pizza!
Pizza face meaning & definition 4 of Pizza face.
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A face covered in blood, resulting from eating out a girl while she is menstruating, and the untimely menstrual discharge covering the munchers face.
Pizza face meaning & definition 5 of Pizza face.
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When your acne is so bad that your face looks like a pizza
Pizza face meaning & definition 6 of Pizza face.
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