Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Tweaked
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To be high on methamphetamine. NOT hallucinates
Tweaked meaning & definition 1 of Tweaked.
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Out of sorts, or on drugs.
Tweaked meaning & definition 2 of Tweaked.
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An idea that just appeared. When your mind brings a solution to something into your thoughts.
Tweaked meaning & definition 3 of Tweaked.
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Become influenced by drugs or Foreign substances...in a bad way
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IT. To say you fixed something on a PC or Server when you really broke it, and really broke it goood.
Tweaked meaning & definition 4 of Tweaked.
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Jonesing.
Completely disoriented.Tweaked meaning & definition 5 of Tweaked.
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Tweaked meaning & definition 6 of Tweaked.
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angry, irritated, pissed
Tweaked meaning & definition 7 of Tweaked.
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[twisted] generally related to events perceived while on hallucinogenic drugs, usually referring to an individual.
Tweaked meaning & definition 8 of Tweaked.
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[made by the girls of (look up) st. josephs academy]--when a girl gets eatin out
Tweaked meaning & definition 9 of Tweaked.
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[twisted] generally related to events perceived while on hallucinogenic drugs, usually referring to an individual.
Tweaked meaning & definition 10 of Tweaked.
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[made by the girls of (look up) st. josephs academy]--when a girl gets eatin out
Tweaked meaning & definition 11 of Tweaked.
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to get really fucking hyped up on energy shots
Tweaked meaning & definition 12 of Tweaked.
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past simple and past participle of tweak
Tweaked meaning & definition 13 of Tweaked.