Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Feeze
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(verb transitive)(as defined in the childrens book ) to fart and sneeze simultaneously. See also [snart]
Feeze meaning & definition 1 of Feeze.
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[substitution] for [fuck]
Feeze meaning & definition 2 of Feeze.
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The result [sneezing] [so hard] that you [fart] at the same time.
Feeze meaning & definition 3 of Feeze.
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When you [sneeze] [with food] [in your mouth].
Feeze meaning & definition 4 of Feeze.
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[This is a word] to describe what happens when you fart and [sneeze] at the same time.
FVFN [8 years] oldFeeze meaning & definition 5 of Feeze.
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