Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Lavette
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People with this name tend to be a powerful force to all whose lives they touch. They are capable, charismatic leaders who often undertake large endeavors with great success. They value truth, justice, and discipline, and may be quick-tempered with those who do not. If they fail to develop their potential, they may become impractical and rigid.
Lavette meaning & definition 1 of Lavette.
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A verb meaning to skin your knee while snorting coke off the sidewalk.
Lavette meaning & definition 2 of Lavette.
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