Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Fustigate
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the action of beating somthing to a grousemly large extent.
This word was made popular in the simpsons episode The Homer They Fall were a character Moe referd to a boxer Dreaderick Tatum will [fustigate] Homer Simpson
Fustigate meaning & definition 1 of Fustigate.
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To beat with a stick or a club.
Fustigate meaning & definition 2 of Fustigate.
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to beat profusely as with a large stick or with bare hands, to fuck up, a red ass beat down.
Fustigate meaning & definition 3 of Fustigate.
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to be beaten with a stick until close to death
Fustigate meaning & definition 4 of Fustigate.
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