Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Stigmata
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Stigmata consists of five classic points where wounds appear: the side, both hands and both feet. Traditionally these are known as the Five Wounds or the Sacred Wounds of our Lord, because they are the marks that occurred at the time of the Crucifixion. Some people are said to suffer the Passion of Christ which includes: the agony at Gethsemane (including the tears or sweating of blood); scourging; the crowning of thorns; beatings; the shoulder sound from carrying the Cross; and the Five Wounds inflicted during the Crucifixion itself.
Stigmata meaning & definition 1 of Stigmata.
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Slang term for the for attire or personal effects of any self-respecting [stiggo].
Usually consists of a Berghaus Jacket, Pri-Mark shellsuit bottoms, and Rockport shoes.
Stigmata meaning & definition 2 of Stigmata.
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marks that appear on a persons body in the same places as those made on Jesus body when he was fastened to a cross with nails
Stigmata meaning & definition 3 of Stigmata.