Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Cracka jack
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Cracka jack is the word used whilst wanna-be gangsta caucasians address each other in a conversation.
Cracka jack meaning & definition 1 of Cracka jack.
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one who is a very silly goose
Cracka jack meaning & definition 2 of Cracka jack.
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mmmm cracka jacks are goood
or sucka ro maybe bitch, or sucka jack
tht whiute kid at our skewl named jack
all meens the same thing cept for the first defCracka jack meaning & definition 3 of Cracka jack.
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