Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Nudist
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A person that typically prefers not to wear clothes when the situation permits. Not to be confused with [streaker].
Nudist meaning & definition 1 of Nudist.
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nudists are generally pedophiles in disguise... (on the internet at least)
Nudist meaning & definition 2 of Nudist.
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people who are naked. They get better health by being outside in the cold winter air, which is equel to a 30 minute workout in the gym. and they get silky hair while they have refreshing sleep. They become more lean, do to chemical reasons, and they shave their dogs and childrens hair so as the whole family is nude.
Nudist meaning & definition 3 of Nudist.
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Should be called oldist since its usually ugly old wrinklies cavorting in the buff.
Nudist meaning & definition 4 of Nudist.
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