Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Hacky
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North Eastern term
Hacky - to be mucky or dirty
Hacky meaning & definition 1 of Hacky.
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To give somebody an evil look, or a look of disgust.
Used frequently in Newcatle upon Tyne and surrounding areas.Hacky meaning & definition 2 of Hacky.
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Dirty or scummy, a northern/geordie word similar to [manky]
Hacky meaning & definition 3 of Hacky.
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Adj. hackneyed productions for media consumption; e.g. television and radio shows, movies, etc.
Hacky meaning & definition 4 of Hacky.
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Lacking originality; hackneyed.
Hacky meaning & definition 5 of Hacky.
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