Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Wedging
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Wedging is when you stay up for long periods of a time a start getting delirious.
Commonly used by 13 year olds or [ptots] that like to say they get high by wedging
Wedging meaning & definition 1 of Wedging.
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present participle of wedge
Wedging meaning & definition 2 of Wedging.
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