Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the Hedgehog protein and controls its spatial distribution, in part via endocytosis of bound Hedgehog protein, which is then targeted for lysosomal degradation.
Water cup
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A water cup refers to someone who goes out to party but either drinks/smokes barely anything or stays completely sober. These people are called water cups because their cups never have alcohol in them. Can also be used as a verb to proclaim that someones not gonna get fucked up that night.
Water cup meaning & definition 1 of Water cup.
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